Lymphocyte repertoires include T and B cell receptor repertoires, diversified by variable region gene rearrangement and selected based on functionality and non-self reactivity, and natural killer (NK) cell repertoires, in which each cell expresses a randomly chosen subset of its inhibitory receptor genes, and educated based on self-MHC recognition by yet unknown mechanisms. Repertoires can also be defined based on phenotype and function - such as the diversity of T helper cell subsets - rather than receptor specificity. Studying the generation, development and selection of lymphocyte repertoires, and their functions during immune responses, is essential for understanding the function of the immune system in healthy individuals and in immune deficient, autoimmune disease or cancer patients. The recent development of high-throughput methods for repertoire data collection - from multicolor flow cytometry through single-cell imaging to deep sequencing - presents us now, for the first time, with the ability to analyze and compare large samples of lymphocyte repertoires in health, aging and disease. The exponential growth of these datasets, however, challenges the theoretical immunology community to develop methods for data organization and analysis. Furthermore, the need to test hypotheses regarding immune function, and generate predictions regarding the outcomes of medical interventions, necessitates the development of complex mathematical and computational models, covering processes on multiple scales, from the genetic and molecular to the cellular and system scales. These new methods and the insights they yield are the topic of this workshop.

Confirmed speakers
Becca Asquith, Imperial College London, London, UK
Mira Barda-Saad, Bar-Ilan University, Ramat-Gan, Israel
Robin Callard
, University College London, London, UK
Michael Cancro, University of Pennsylvania Medical School, Philadelphia, PA, USA
Francesca Chiodi, Karolinska Institute, Stockholm, Sweden
Andrew Collins, University of New South Wales, Sydney, Australia
Miles Davenport, University of New South Wales, Sydney,  Australia
Rob J. De Boer, Utrecht University, Utrecht, The Netherlands
Deborah Dunn-Walters, King's College, London, UK
Omer Dushek, University of Oxford, Oxford, UK
Sol Efroni, Bar-Ilan University, Ramat-Gan, Israel
Nir Friedman, Weizmann Institute of Science, Rehovot, Israel
Vitaly Ganusov
, University of Tennessee, Knoxville, TN
, USA
Uri Hershberg
, Drexel University, Philadelphia, PA, USA
Philip Hodgkin, Walter & Eliza Hall Institute, Melbourne, Australia
Klas Kärre, Karolinska Institute, Stockholm, Sweden
Thomas B. Kepler, Duke University, Durham, NC, USA
Yoram Louzoun, Bar-Ilan University, Ramat-Gan, Israel
Ramit Mehr, Bar-Ilan University, Ramat-Gan, Israel
Yanai Ofran, Bar-Ilan University, Ramat-Gan, Israel
Paolo Ubezio, Mario Negri Cancer Institute, Milano, Italy
Aleksandra Walczak
, Ecole Normale Superieure, Paris, France
Gur Yaari
, Yale University, New Haven, CT, USA

Local organizing committee:
Ramit Mehr, Bar-Ilan University
Iris Barshack
, Sheba Medical Center + Tel-Aviv University
Mira Barda-Saad
, Bar-Ilan University
Ron Unger
, Bar-Ilan University
Yoram Louzoun
, Bar-Ilan University
Yanay Ofran
, Bar-Ilan University
Sol Efroni
, Bar-Ilan University
Nir Friedman, Weizmann Institute

Scientific advisory committee:
Rob J.  De Boer, Utrecht University, Utrecht, The Netherlands
Philip  Hodgkin
, Walter & Eliza Hall Institute, Melbourne, Australia
Alan  Perleson
, Los Alamos National Laboratory, Los Alamos, NM, USA
Jorge  Carneiro
, Instituto Gulbenkian de Ciencia, Lisbon, Portugal
Andrew  Collins
, University of New South Wales, Sydney, Australia
Paolo Ubezio
, Mario Negri Cancer Institute, Milano, Italy

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